(4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Base Information

Chemical Name:(4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
CAS No.:1301212-63-4
Molecular Formula:C₂₈H₄₄O₆
Molecular Weight:476.654
Hs Code.:

Synonyms:(4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

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Chemical Property of (4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

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Technology Process of (4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

There total 1 articles about (4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863239-59-2,1516887-31-2
3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester

: 1301212-63-4
(4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; platinum(IV) oxide; hydrogen; acetic acid / 24 h / 1654.92 Torr

2: sodium hydroxide / methanol

3: sodium tetrahydroborate; water / tetrahydrofuran / 20 °C

4: toluene-4-sulfonic acid / benzene / 2 h / Reflux

With hydrogenchloride; platinum(IV) oxide; sodium tetrahydroborate; water; hydrogen; toluene-4-sulfonic acid; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; benzene;
DOI:10.1016/j.bmc.2011.03.004

Reference yield:

: 1301212-63-4
(4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

: C₃₂H₄₈O₄

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 2 h / 25 °C

1.2: 0 - 25 °C

2.1: lead acetate; copper diacetate; pyridine / toluene / 12 h / 110 °C

3.1: tetrabutylammomium bromide; sodium carbonate; palladium diacetate / N,N-dimethyl-formamide / 12 h / 85 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 25 °C / 775.74 Torr

5.1: water; lithium hydroxide / methanol; tetrahydrofuran / 12 h / 20 °C

With pyridine; palladium 10% on activated carbon; tetrabutylammomium bromide; water; hydrogen; copper diacetate; palladium diacetate; lead acetate; chloroformic acid ethyl ester; sodium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1301212-63-4
(4R)-4-((3R,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

: C₃₂H₄₆O₄

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 2 h / 25 °C

1.2: 0 - 25 °C

2.1: lead acetate; copper diacetate; pyridine / toluene / 12 h / 110 °C

3.1: tetrabutylammomium bromide; sodium carbonate; palladium diacetate / N,N-dimethyl-formamide / 12 h / 85 °C / Inert atmosphere

4.1: water; lithium hydroxide / methanol; tetrahydrofuran / 12 h / 20 °C

With pyridine; tetrabutylammomium bromide; water; copper diacetate; palladium diacetate; lead acetate; chloroformic acid ethyl ester; sodium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;