(S)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-6-methyluracil

Base Information

Chemical Name:(S)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-6-methyluracil
CAS No.:732282-75-6
Molecular Formula:C₂₃H₃₀BrF₂N₃O₄
Molecular Weight:530.41
Hs Code.:

Synonyms:(S)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-6-methyluracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-6-methyluracil

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Technology Process of (S)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-6-methyluracil

There total 1 articles about (S)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-6-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82010-31-9
(S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester

: 352303-66-3
5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

: 732282-75-6
(S)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-6-methyluracil

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1021/jm049791w

Reference yield:

: 352303-67-4
(2-fluoro-3-methoxyphenyl)boronic acid

: 732282-75-6
(S)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-6-methyluracil

: 732282-84-7
(S)-3-(N-tert-butoxycarbonyl-2-amino-4-methylpentyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Guidance literature:: With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; benzene; at 80 ℃; for 16h;
DOI:10.1021/jm049791w