ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate

Base Information

• Chemical Name: ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate
• CAS No.: 1403576-32-8
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• Mol file: 1403576-32-8.mol

Synonyms:ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate

Chemical Property of ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate

There total 3 articles about ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl 3-amino-4-(2-hydroxyethylamino)benzoate (91430-70-5) + Sodium; hydroxy-o-tolyl-methanesulfonate → ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate (1403576-32-8)

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 0.0416667h; Microwave irradiation;

DOI:10.3390/molecules17089887

Reference yield:

ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate (91214-94-7) → ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate (1403576-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 10% Pd/C; ammonium formate / ethanol / 0.03 h / 100 °C / Microwave irradiation

2: N,N-dimethyl-formamide / 0.04 h / 130 °C / Microwave irradiation

With 10% Pd/C; ammonium formate; In ethanol; N,N-dimethyl-formamide;

DOI:10.3390/molecules17089887

Reference yield:

ethyl 4-fluoro-3-nitrobenzoate (367-80-6) → ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate (1403576-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: 10% Pd/C; ammonium formate / ethanol / 0.03 h / 100 °C / Microwave irradiation

3: N,N-dimethyl-formamide / 0.04 h / 130 °C / Microwave irradiation

With 10% Pd/C; ammonium formate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules17089887

upstream raw materials:

ethyl 3-amino-4-(2-hydroxyethylamino)benzoate

ethyl 4-fluoro-3-nitrobenzoate

ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate

Downstream raw materials:

C₅₃H₅₄N₂O₈

C₂₅H₃₀N₂O₈