ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate

Base Information

• Chemical Name: ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate
• CAS No.: 91214-94-7
• Molecular Formula: C₁₁H₁₄N₂O₅
• Molecular Weight: 254.243
• Mol file: 91214-94-7.mol

Synonyms:ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate

Chemical Property of ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate

There total 4 articles about ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 4-fluoro-3-nitrobenzoate (367-80-6) + ethanolamine (141-43-5) → ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate (91214-94-7)

Guidance literature:

In ethanol; at 20 ℃; for 1h; Green chemistry;

DOI:10.2174/157017861110141117150010

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate (91214-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 8 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.3390/molecules17089887

Reference yield:

C10H6FN3O3 → ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate (91214-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Imidazole hydrochloride / 0.5 h / 20 °C / Green chemistry

2: ethanol / 1 h / 20 °C / Green chemistry

With Imidazole hydrochloride; In ethanol;

DOI:10.2174/157017861110141117150010

upstream raw materials:

3-nitro-4-fluorobenzoic acid

ethyl 4-fluoro-3-nitrobenzoate

ethanolamine

Downstream raw materials:

ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzo[d]imidazole-5-carboxylate

ethyl 1-(2-hydroxyethyl)-2-o-tolyl-1H-benzimidazole-5-carboxylate

ethyl 1-(2-hydroxyethyl)-2-p-tolyl-1H-benzo[d]imidazole-5-carboxylate

ethyl 1-(2-hydroxyethyl)-2-(4-methoxyphenyl)-1H-benzimidazole-5-carboxylate