12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁵⁾,11,13-triene

Base Information

• Chemical Name: 12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁵⁾,11,13-triene
• CAS No.: 227457-59-2
• Molecular Formula: C₁₈H₂₃BrN₄O
• Molecular Weight: 391.311

Synonyms:12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁵⁾,11,13-triene

Chemical Property of 12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁵⁾,11,13-triene

Chemical Property:

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Technology Process of 12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁵⁾,11,13-triene

There total 7 articles about 12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁵⁾,11,13-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

12-[(4-bromobenzyl)oxy]-3,6,9-tris(diethoxyphosphoryl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene → 12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene (227457-59-2)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In 1,4-dioxane; at 20 ℃;

DOI:10.1002/(SICI)1522-2675(20000412)83:4<793::AID-HLCA793>3.0.CO;2-3

Reference yield: 80.0%

12-(4-Bromobenzyloxy)-3,6,9-tris(2-nitrobenzenesulfonyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene (227457-58-1) → 12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene (227457-59-2)

Guidance literature:

With lithium hydroxide; mercaptoacetic acid; In N,N-dimethyl-formamide; at 22 ℃; for 5h;

DOI:10.1002/(SICI)1521-3765(19990401)5:4<1253::AID-CHEM1253>3.0.CO;2-I

Reference yield:

3-(4-Bromobenzyloxy)-2,6-bis(chloromethyl)pyridine (227457-57-0) → 12-[(4-bromobenzyl)oxy]-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene (227457-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / Bu₄N(HSO₄); aq. 50 percent NaOH / toluene / Heating

2: 95 percent / HCl gas; NaOH / dioxane / 20 °C

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; toluene; 1: Condensation / 2: Hydrolysis;

DOI:10.1002/(SICI)1522-2675(20000412)83:4<793::AID-HLCA793>3.0.CO;2-3

upstream raw materials:

12-(4-Bromobenzyloxy)-3,6,9-tris(2-nitrobenzenesulfonyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁵⁾,11,13-triene

3-(4-Bromobenzyloxy)-2,6-bis(chloromethyl)pyridine

3-HYDROXYPYRIDINE

2,6-bis-(hydroxymethyl)-3-hydroxypyridine

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