(2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid

Base Information

Chemical Name:(2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid
CAS No.:190904-21-3
Molecular Formula:C₂₀H₃₅NO₆
Molecular Weight:385.501
Hs Code.:

Synonyms:(2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid

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Technology Process of (2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid

There total 13 articles about (2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 190904-19-9
N-(tert-butyloxycarbonylmethyl)-N-Boc-D-Cha-OMe

: 190904-21-3
(2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; Ambient temperature;
DOI:10.1016/S0960-894X(98)00650-7

Reference yield:

: 58717-02-5
3-cyclohexyl-D-alanine

: 190904-21-3
(2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / toluene

2: i-Pr₂NEt / dimethylformamide / 20 h

3: i-Pr₂NEt / dimethylformamide / 24 h / 40 °C

4: H₂; Pd/C / various solvent(s) / 750.06 - 1500.12 Torr

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2004-831200

Reference yield:

: 203789-94-0
N-Boc-N-(tert-butyloxycarbonylmethylene)-(D)-cyclohexylalanine benzyl ester

: 190904-21-3
(2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid

Guidance literature:: With palladium on activated charcoal; hydrogen; In various solvent(s); under 750.06 - 1500.12 Torr;
DOI:10.1055/s-2004-831200