2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

Base Information

Chemical Name:2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone
CAS No.:75817-49-1
Molecular Formula:C₂₂H₃₂O₂Si
Molecular Weight:356.58
Hs Code.:

Synonyms:2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

Chemical Property:

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Technology Process of 2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

There total 10 articles about 2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64166-04-7
3-vinyl-2-methyl-1-trimethylsilyloxy-1-cyclopentene

: 75817-48-0
1-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-prop-2-en-1-ol

: 75817-49-1
(2S,3S)-2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

: 75817-49-1
(2S,3R)-2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

Guidance literature:: With zinc dibromide; In dichloromethane; at -78 - -20 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/ja00542a055

Reference yield:

: 64166-04-7
3-vinyl-2-methyl-1-trimethylsilyloxy-1-cyclopentene

: 75817-48-0
1-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-prop-2-en-1-ol

: 75817-49-1
(2S,3S)-2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

: 75817-49-1
(2S,3R)-2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

Guidance literature:: With zinc dibromide; In dichloromethane; at -78 - -20 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/ja00542a055

Reference yield:

: 53416-46-9
2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 75817-49-1
(2S,3S)-2-[(E)-3-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-allyl]-2-methyl-3-vinyl-cyclopentanone

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / n-BuLi / diethyl ether

2: 92 percent / n-BuLi

3: 1.) methyl iodide, 2.) NaBH₄ / 1.) nitromethane, 2.) ethanol

4: 95 percent

5: zinc bromide / CH₂Cl₂ / -78 - -20 °C

With sodium tetrahydroborate; n-butyllithium; zinc dibromide; methyl iodide; In diethyl ether; dichloromethane;
DOI:10.1021/ja00542a055