(R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine

Base Information

Chemical Name:(R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine
CAS No.:1268832-95-6
Molecular Formula:C₂₁H₃₇NO₃SSi
Molecular Weight:411.681
Hs Code.:

Synonyms:(R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine

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Chemical Property of (R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine

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Technology Process of (R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine

There total 4 articles about (R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1268832-94-5
N-((2R,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-hydroxybutan-2-yl)-2,4,6-trimethylbenzenesulfonamide

: 1268832-95-6
(R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine

Guidance literature:: N-((2R,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-hydroxybutan-2-yl)-2,4,6-trimethylbenzenesulfonamide; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

With potassium hydroxide; In dichloromethane; water;
DOI:10.1021/ol103145g

Reference yield:

: 773-64-8
2-mesitylenesulphonyl chloride

: 1268832-95-6
(R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane

2: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: methanol; lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: methanesulfonyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; methanol; lithium borohydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol103145g

Reference yield:

: C₂₂H₃₉NO₅SSi

: 1268832-95-6
(R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: methanesulfonyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With methanol; lithium borohydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol103145g