N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide

Base Information

Chemical Name:N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide
CAS No.:1268832-96-7
Molecular Formula:C₃₃H₄₈NO₃PSSi
Molecular Weight:597.874
Hs Code.:

Synonyms:N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide

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Technology Process of N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide

There total 5 articles about N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1268832-95-6
(R)-2-((R)-1-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)ethyl)-1-(mesitylsulfonyl)aziridine

: 4376-01-6
sodium diphenylphosphide

: 1268832-96-7
N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide

Guidance literature:: In tetrahydrofuran; 1,4-dioxane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol103145g

Reference yield:

: 773-64-8
2-mesitylenesulphonyl chloride

: 1268832-96-7
N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane

2: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: methanol; lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: methanesulfonyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

5: tetrahydrofuran; 1,4-dioxane / 1 h / 0 °C / Inert atmosphere

With 1H-imidazole; methanol; lithium borohydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol103145g

Reference yield:

: 1268832-94-5
N-((2R,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-hydroxybutan-2-yl)-2,4,6-trimethylbenzenesulfonamide

: 1268832-96-7
N-((2S,3R)-3-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-2,4,6-trimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran; 1,4-dioxane / 1 h / 0 °C / Inert atmosphere

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/ol103145g