Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate

Base Information

Chemical Name:Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate
CAS No.:98008-65-2
Molecular Formula:C₃₄H₄₀O₆
Molecular Weight:544.688
Hs Code.:

Synonyms:Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate

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Chemical Property of Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate

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Technology Process of Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate

There total 7 articles about Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 98008-61-8
3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde

: 98008-65-2
Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/0039-128X(89)90076-7

Reference yield:

: 2590-41-2
6-dehydro-19-nortestosterone acetate

: 98008-65-2
Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate

Guidance literature:: Multi-step reaction with 7 steps

1: 46 percent / Mg, CuI / tetrahydrofuran

2: 1) aq. AcOH, 2) pyridine / 1) THF, 50 deg C, 2) r.t.

3: CuBr₂, LiBr / acetonitrile / Heating

4: aq. 1N NaOH / methanol / Ambient temperature

5: aq. 1 N NaOH / acetone / 0 °C

6: 80 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

7: 90 percent / NaH / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; sodium hydroxide; copper(l) iodide; sodium hydride; magnesium; acetic acid; pyridinium chlorochromate; lithium bromide; copper(ll) bromide; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1016/0039-128X(89)90076-7

Reference yield:

: Acetic acid (7R,8R,9S,13S,14S,17S)-3-hydroxy-7-(3-hydroxy-propyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

: 98008-65-2
Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. 1 N NaOH / acetone / 0 °C

2: 80 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

3: 90 percent / NaH / tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/0039-128X(89)90076-7