3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde

Base Information

• Chemical Name: 3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde
• CAS No.: 98008-61-8
• Molecular Formula: C₃₀H₃₄O₅
• Molecular Weight: 474.597
• Mol file: 98008-61-8.mol

Synonyms:3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde

Chemical Property of 3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde

There total 7 articles about 3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol (98008-60-7) → 3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde (98008-61-8)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 2h;

DOI:10.1016/0039-128X(89)90076-7

Reference yield:

6-dehydro-19-nortestosterone acetate (2590-41-2) → 3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde (98008-61-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 46 percent / Mg, CuI / tetrahydrofuran

2: 1) aq. AcOH, 2) pyridine / 1) THF, 50 deg C, 2) r.t.

3: CuBr₂, LiBr / acetonitrile / Heating

4: aq. 1N NaOH / methanol / Ambient temperature

5: aq. 1 N NaOH / acetone / 0 °C

6: 80 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

With pyridine; sodium hydroxide; copper(l) iodide; magnesium; acetic acid; pyridinium chlorochromate; lithium bromide; copper(ll) bromide; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;

DOI:10.1016/0039-128X(89)90076-7

Reference yield:

Acetic acid (7R,8R,9S,13S,14S,17S)-3-hydroxy-7-(3-hydroxy-propyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester → 3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde (98008-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. 1 N NaOH / acetone / 0 °C

2: 80 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

With sodium hydroxide; pyridinium chlorochromate; In dichloromethane; acetone;

DOI:10.1016/0039-128X(89)90076-7

upstream raw materials:

3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol

6-dehydro-19-nortestosterone acetate

Acetic acid (7R,8R,9S,10R,13S,14S,17S)-7-(3-acetoxy-propyl)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Acetic acid (7R,8R,9S,13S,14S,17S)-7-(3-acetoxy-propyl)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Downstream raw materials:

Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pentanoate

Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate