(3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene

Base Information

Chemical Name:(3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene
CAS No.:530147-10-5
Molecular Formula:C₄₅H₈₄O₃Si₃
Molecular Weight:757.417
Hs Code.:

(3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene

Synonyms:(3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene

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Chemical Property of (3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene

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Technology Process of (3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene

There total 4 articles about (3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 116506-67-3
TB

: 530147-04-7
(6R)-6-[(1R,3aR,7aR)-4-(trifluoromethanesulfonyloxy)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-1-yl]-2-methyl-2-(triethylsilyloxy)heptane

: 530147-10-5
(3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene

Guidance literature:: With copper(l) iodide; diethylamine; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1039/b209147j

Reference yield:

: 994-30-9
triethylsilyl chloride

: 530147-10-5
(3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / DMAP / CH₂Cl₂ / 12 h / 20 °C

2.1: i-Pr₂NH; n-BuLi / tetrahydrofuran; hexane / 2.75 h / -78 - 20 °C

2.2: 258 mg / tetrahydrofuran; hexane / 250 h / -78 - 20 °C

3.1: 86 percent / CuI; Et₂NH / bis(triphenylphosphine)palladium (II) acetate / acetonitrile / 1 h / 20 °C

With dmap; copper(l) iodide; n-butyllithium; diethylamine; diisopropylamine; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1039/b209147j

Reference yield:

: 70550-73-1
(1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-2-yl]-7a-methyloctahydroinden-4-one

: 530147-10-5
(3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / DMAP / CH₂Cl₂ / 12 h / 20 °C

2.1: i-Pr₂NH; n-BuLi / tetrahydrofuran; hexane / 2.75 h / -78 - 20 °C

2.2: 258 mg / tetrahydrofuran; hexane / 250 h / -78 - 20 °C

3.1: 86 percent / CuI; Et₂NH / bis(triphenylphosphine)palladium (II) acetate / acetonitrile / 1 h / 20 °C

With dmap; copper(l) iodide; n-butyllithium; diethylamine; diisopropylamine; bis(acetato)bis(triphenylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1039/b209147j