N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester

Base Information

• Chemical Name: N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester
• CAS No.: 256478-22-5
• Molecular Formula: C₂₂H₂₄ClN₅O₄S
• Molecular Weight: 489.983
• Mol file: 256478-22-5.mol

Synonyms:N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester

Chemical Property of N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester

There total 17 articles about N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester (256477-30-2) + CH2Cl2-MeOH-0.880NH3 + guanidine hydrochloride (50-01-1) → N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine t-butyl ester (256478-22-5)

Guidance literature:

With NaH; In 1,2-dimethoxyethane; mineral oil;

Reference yield:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester (256477-30-2) + N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine trifluoroacetate + CH2 Cl2 -MeOH-0.880N3 + guanidine hydrochloride (50-01-1) → N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine t-butyl ester (256478-22-5)

Guidance literature:

With NaH; In 1,2-dimethoxyethane; mineral oil;

Reference yield:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester (256477-30-2) + guanidine hydrochloride (50-01-1) → N-[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester (256478-22-5)

Guidance literature:

guanidine hydrochloride; With sodium hydride; In 1,2-dimethoxyethane; at 60 ℃; for 0.5h;

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester; In 1,2-dimethoxyethane; at 95 ℃; for 6h; Further stages.;

DOI:10.1021/jm061066t

upstream raw materials:

N-[(1,4-dichloro-7-isoquinolinyl)sulphonyl]-N-phenylglycine tert-butyl ester

guanidine hydrochloride

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride

4-chloro-1-(2H)-isoquinolone