2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Base Information

• Chemical Name: 2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine
• CAS No.: 162434-89-1
• Molecular Formula: C₂₅H₃₄N₆O₇Si
• Molecular Weight: 558.666

Synonyms:2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Chemical Property of 2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Chemical Property:

Purity/Quality:

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Technology Process of 2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

There total 2 articles about 2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-88-0) → 2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-89-1)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1002/hlca.19940770707

Reference yield:

TsOH *H2 O + 2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-88-0) → 2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-89-1)

Guidance literature:

In methanol; dichloromethane;

Reference yield:

cholesterol (57-88-5) + 2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-89-1) → 5'-O-[2-(cholesteryloxy-carbonyl)ethylcarbonyl]-3'-deoxy-6-N-[2-(4-nitrophenyl)ethoxycarbonyl]-adenosine + 2'-O-[2-(Cholesteryloxycarbonyl)ethylcarbonyl]-3'-deoxy-5'-O-monomethoxytrityl-6-N-[2-(4-nitrophenyl)ethoxycarbonyl]-adenosine

Guidance literature:

With dmap; 1,2-dichloro-ethane; In dichloromethane; ethyl acetate; toluene; 3'-deoxy-5'-O-monomethoxytrityl-6-N-[2-(4-nitrophenyl)-ethoxycarbonyl]-adenosine;

upstream raw materials:

2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Downstream raw materials:

C₅₆H₈₂N₆O₁₀Si

5'-O-<<2-(cholest-5-en-3β-yloxycarbonyl)ethyl>carbonyl>-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

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