(S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester

Base Information

Chemical Name:(S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester
CAS No.:236110-99-9
Molecular Formula:C₂₇H₂₈N₂O₅
Molecular Weight:460.53
Hs Code.:

(S)-(-)-3-<4-<2-<N-(2-benzoxazolyl)-N-methylamino>ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester

Synonyms:(S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester

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Chemical Property of (S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester

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Technology Process of (S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester

There total 6 articles about (S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 158062-06-7
methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoate

: 236110-99-9
(S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / aq. NaOH / methanol

2: oxalyl chloride / benzene / 2.5 h / Heating

3: 1.) n-butyllithium / 1.) hexane, THF, -70 deg C, 10 min, 2.) hexane, THF, from -70 deg C to RT, 21 h

4: NaOMe / 0.22 h / 0 °C

With sodium hydroxide; n-butyllithium; oxalyl dichloride; sodium methylate; In methanol; benzene;
DOI:10.1016/S0957-4166(99)00104-4

Reference yield:

: 158062-07-8
methyl 3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid

: 236110-99-9
(S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / benzene / 2.5 h / Heating

2: 1.) n-butyllithium / 1.) hexane, THF, -70 deg C, 10 min, 2.) hexane, THF, from -70 deg C to RT, 21 h

3: NaOMe / 0.22 h / 0 °C

With n-butyllithium; oxalyl dichloride; sodium methylate; In benzene;
DOI:10.1016/S0957-4166(99)00104-4

Reference yield:

: ethyl (E/Z)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropenoate

: 236110-99-9
(S)-(-)-3-<4-<2-ethoxy>phenyl>-2-benzyloxypropanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / Mg, I₂ / 23 h / Ambient temperature

2: 91 percent / aq. NaOH / methanol

3: oxalyl chloride / benzene / 2.5 h / Heating

4: 1.) n-butyllithium / 1.) hexane, THF, -70 deg C, 10 min, 2.) hexane, THF, from -70 deg C to RT, 21 h

5: NaOMe / 0.22 h / 0 °C

With sodium hydroxide; n-butyllithium; oxalyl dichloride; iodine; sodium methylate; magnesium; In methanol; benzene;
DOI:10.1016/S0957-4166(99)00104-4