N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine

Base Information

Chemical Name:N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine
CAS No.:1394387-87-1
Molecular Formula:C₂₁H₂₉N₃O₂
Molecular Weight:355.48
Hs Code.:

Synonyms:N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine

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Chemical Property of N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine

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Technology Process of N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine

There total 7 articles about N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: C₂₁H₂₇N₃O₂

: 1394387-87-1
N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine

Guidance literature:: With sodium tris(acetoxy)borohydride; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.12.056

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1394387-87-1
N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 2 h / 20 °C

1.3: 15 h / -78 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

4.1: hydrazine hydrate / ethanol / 2 h / 70 °C

5.1: dichloromethane / 2 h / Molecular sieve

6.1: sodium tris(acetoxy)borohydride / 2 h / 20 °C

With n-butyllithium; sodium tris(acetoxy)borohydride; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 4.1: |Gabriel Amine Synthesis;
DOI:10.1016/j.ejmech.2013.12.056

Reference yield:

: 138647-51-5
4-(4-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1394387-87-1
N-((3-isopropylisoxazol-5-yl)methyl)-2-(4-(4-methoxyphenyl)-5,6-dihydropyridin-1(2H)-yl)ethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

3: hydrazine hydrate / ethanol / 2 h / 70 °C

4: dichloromethane / 2 h / Molecular sieve

5: sodium tris(acetoxy)borohydride / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; 3: |Gabriel Amine Synthesis;
DOI:10.1016/j.ejmech.2013.12.056