3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride

Base Information

• Chemical Name: 3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride
• CAS No.: 1008529-50-7
• Molecular Formula: C₁₄H₁₂F₃N
• Molecular Weight: 251.251
• Mol file: 1008529-50-7.mol

Synonyms:3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride

Chemical Property of 3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride

There total 1 articles about 3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,3-Dimethylbut-1-yne (917-92-0) + 2-chloro-4-trifluoromethyl-benzonitril (1813-33-8) → 3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride (1008529-50-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; triethylamine; DavePhos; at 65 ℃; for 4h;

DOI:10.1021/jo901943s

Reference yield: 91.0%

3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride (1008529-50-7) + succinic acid (110-15-6) → 4-aminomethyl-3-(3,3-dimethylbutyl)benzotrifluoride succinate (1187763-11-6)

Guidance literature:

3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride; With hydrogen; nickel; potassium hydroxide; In methanol; at 50 ℃; for 42h;

succinic acid; In methanol;

DOI:10.1021/jo901943s

Reference yield:

3-(3,3-dimethylbut-1-ynyl)-4-cyanobenzotrifluoride (1008529-50-7) → (2-(3,3-dimethylbutyl)-4-(trifluoromethyl)phenyl)methanamine (1008529-66-5)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol; for 16h; under 3102.97 Torr;

upstream raw materials:

3,3-Dimethylbut-1-yne

2-chloro-4-trifluoromethyl-benzonitril

Downstream raw materials:

(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)phenyl)methanamine

4-aminomethyl-3-(3,3-dimethylbutyl)benzotrifluoride succinate