(R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate
CAS No.:1387641-80-6
Molecular Formula:C₃₆H₄₂N₄O₈
Molecular Weight:658.751
Hs Code.:

Synonyms:(R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

Suppliers and Price of (R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

There total 13 articles about (R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 943321-68-4
(±)-tert-butyl N-(3-amino-3-phenyl-propyl)carbamate

: 1387641-72-6
3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid

: 1387641-80-6
(R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

: (S)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

Guidance literature:: 3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

(±)-tert-butyl N-(3-amino-3-phenyl-propyl)carbamate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 621-59-0
isovanillin

: 1387641-80-6
(R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

: (S)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 85 °C

2.1: nitric acid / acetic acid / 0.08 h / Cooling with ice

2.2: 4 h / 20 °C / Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

4.1: piperidine / acetic acid / methanol / 60 °C

5.1: sodium hydroxide; water / methanol / 4 h / 60 °C

5.2: pH 3 / Acidic conditions

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

6.2: 20 °C

7.1: sodium hydroxide; water / methanol / 1.5 h / 60 °C

7.2: pH 3

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

8.2: 20 °C

With piperidine; water; hydrogen; nitric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; potassium iodide; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 116168-89-9
4-methoxy-3-(2-methoxyethoxy)benzaldehyde

: 1387641-80-6
(R)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

: (S)-tert-butyl 3-(3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)-4-methylbenzamido)-3-phenylpropylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid / acetic acid / 0.08 h / Cooling with ice

1.2: 4 h / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

3.1: piperidine / acetic acid / methanol / 60 °C

4.1: sodium hydroxide; water / methanol / 4 h / 60 °C

4.2: pH 3 / Acidic conditions

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

5.2: 20 °C

6.1: sodium hydroxide; water / methanol / 1.5 h / 60 °C

6.2: pH 3

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

7.2: 20 °C

With piperidine; water; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;