3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid

Base Information

Chemical Name:3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid
CAS No.:1387641-72-6
Molecular Formula:C₂₂H₂₂N₂O₇
Molecular Weight:426.426
Hs Code.:

Synonyms:3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid

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Chemical Property of 3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid

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Technology Process of 3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid

There total 7 articles about 3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1387641-10-2
3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester

: 1387641-72-6
3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid

Guidance literature:: 3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid methyl ester; With water; sodium hydroxide; In methanol; at 60 ℃; for 1.5h;

With hydrogenchloride; In methanol; water; pH=3;

Reference yield:

: 621-59-0
isovanillin

: 1387641-72-6
3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 85 °C

2.1: nitric acid / acetic acid / 0.08 h / Cooling with ice

2.2: 4 h / 20 °C / Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

4.1: piperidine / acetic acid / methanol / 60 °C

5.1: sodium hydroxide; water / methanol / 4 h / 60 °C

5.2: pH 3 / Acidic conditions

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

6.2: 20 °C

7.1: sodium hydroxide; water / methanol / 1.5 h / 60 °C

7.2: pH 3

With piperidine; water; hydrogen; nitric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; potassium iodide; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: C₁₁H₁₅NO₄

: 1387641-72-6
3-{[7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carbonyl]-amino}-4-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / acetic acid / methanol / 60 °C

2.1: sodium hydroxide; water / methanol / 4 h / 60 °C

2.2: pH 3 / Acidic conditions

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

3.2: 20 °C

4.1: sodium hydroxide; water / methanol / 1.5 h / 60 °C

4.2: pH 3

With piperidine; water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; acetic acid; In methanol; N,N-dimethyl-formamide;