N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide

Base Information

• Chemical Name: N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide
• CAS No.: 1443251-42-0
• Molecular Formula: C₂₇H₂₄N₂O₃
• Molecular Weight: 424.499

Synonyms:N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide

Chemical Property of N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide

There total 4 articles about N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1,1-diphenyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-3(1H)-one (1443251-67-9) + benzyl isothiocyanate (3173-56-6) → N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide (1443251-42-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.3390/ph14101024

Reference yield:

cinchomeronic anhydride (4664-08-8) → N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide (1443251-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / -78 - 20 °C

2: hydrogen; hydrogenchloride; platinum(IV) oxide / ethanol / 4 h / 2068.65 Torr

3: dichloromethane / 1 h / 20 °C

With hydrogenchloride; platinum(IV) oxide; hydrogen; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.3390/ph14101024

Reference yield:

phenylmagnesium bromide (100-58-3) → N-benzyl-3-oxo-1,1-diphenyl-3,4,6,7-tetrahydrofuro[3,4-c]pyridine-5(1H)-carboxamide (1443251-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / -78 - 20 °C

2: hydrogen; hydrogenchloride; platinum(IV) oxide / ethanol / 4 h / 2068.65 Torr

3: dichloromethane / 1 h / 20 °C

With hydrogenchloride; platinum(IV) oxide; hydrogen; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.3390/ph14101024

upstream raw materials:

1,1-diphenyl-4,5,6,7-tetrahydrofuro[3,4-c]pyridin-3(1H)-one

benzyl isothiocyanate

phenylmagnesium bromide

cinchomeronic anhydride

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