(-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone

Base Information

Chemical Name:(-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone
CAS No.:929217-55-0
Molecular Formula:C₂₁H₂₂O₆
Molecular Weight:370.402
Hs Code.:

Synonyms:(-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone

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Chemical Property of (-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone

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Technology Process of (-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone

There total 2 articles about (-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 63126-29-4,74752-95-7
(4R,5R)-2,2,N,N,N',N'-hexamethyl-1,3-dioxolane-4,5-dicarboxamide

: 16750-63-3
2-methoxyphenylmagnesium bromide

: 929217-55-0
(-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone

: 1070872-72-8
(-)-(4R,5R)-5-(2-methoxy-benzoyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide

Guidance literature:: In tetrahydrofuran; at -10 ℃; for 1.5h;
DOI:10.1021/jo8013403

Reference yield: 55.0%

: 177283-77-1
(4R,5R)-N,N'-dimethoxy-N,N',2,2-tetramethyl-1,3-dioxolane-4,5-dicarboxamide

: 929217-55-0
(-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone

Guidance literature:: In tetrahydrofuran; at -10 ℃; for 3h;
DOI:10.1021/jo062016z

Reference yield:

: 929217-55-0
(-)-((4R,5R)-5-(2-methoxybenzoyl)-2,2-dimethyl-[1,3]dioxolan-4-yl)-(2-methoxyphenyl)-methanone

: (+)-{(4R,5R)-2,2-dimethyl-5-[(S)-2,2,2-trifluoro-1-hydroxy-1-(2-methoxyphenyl)ethyl]-[1,3]dioxolan-4-yl}-(2-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / -40 °C

2: tetra-n-butylammonium fluoride trihydrate / CH₂Cl₂ / 3 h / 20 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo062016z