C₁₈H₂₀N₄O₄

Base Information

Chemical Name:C₁₈H₂₀N₄O₄
CAS No.:1350709-49-7
Molecular Formula:C₁₈H₂₀N₄O₄
Molecular Weight:356.381
Hs Code.:

C<sub>18</sub>H<sub>20</sub>N<sub>4</sub>O<sub>4</sub>

Synonyms:C₁₈H₂₀N₄O₄

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Chemical Property of C₁₈H₂₀N₄O₄

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Technology Process of C₁₈H₂₀N₄O₄

There total 4 articles about C₁₈H₂₀N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1431551-49-3
C₂₄H₃₄N₄O₅Si

: 1350709-49-7
C₁₈H₂₀N₄O₄

Guidance literature:: C₂₄H₃₄N₄O₅Si; With hydrogenchloride; In water; acetic acid; at 65 ℃; for 3h;

With methanol; ethylenediamine; triethylamine; In water; at 0 - 25 ℃; for 18h;
DOI:10.1016/j.bmcl.2013.03.015

Reference yield:

: 1185428-34-5
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde

: 1350709-49-7
C₁₈H₂₀N₄O₄

Guidance literature:: Multi-step reaction with 4 steps

1.1: aminosulfonic acid; sodium chlorite; potassium dihydrogenphosphate / 1,4-dioxane; water / 2.75 h / 0 - 20 °C

2.1: HATU / N,N-dimethyl-formamide / 20 °C

3.1: palladium diacetate; potassium phosphate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 18 h / 140 °C / Inert atmosphere; Sealed tube

4.1: hydrogenchloride / water; acetic acid / 3 h / 65 °C

4.2: 18 h / 0 - 25 °C

With hydrogenchloride; sodium chlorite; potassium phosphate; potassium dihydrogenphosphate; aminosulfonic acid; palladium diacetate; HATU; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide; toluene; 3.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2013.03.015

Reference yield:

: 1334674-90-6
2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

: 1350709-49-7
C₁₈H₂₀N₄O₄

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU / N,N-dimethyl-formamide / 20 °C

2.1: palladium diacetate; potassium phosphate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 18 h / 140 °C / Inert atmosphere; Sealed tube

3.1: hydrogenchloride / water; acetic acid / 3 h / 65 °C

3.2: 18 h / 0 - 25 °C

With hydrogenchloride; potassium phosphate; palladium diacetate; HATU; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In water; acetic acid; N,N-dimethyl-formamide; toluene; 2.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2013.03.015