Boc-Phe-Ala-OBz

Base Information

• Chemical Name: Boc-Phe-Ala-OBz
• CAS No.: 74257-68-4
• Molecular Formula: C₂₄H₃₀N₂O₅
• Molecular Weight: 426.513
• Mol file: 74257-68-4.mol

Synonyms:Boc-Phe-Ala-OBz

Chemical Property of Boc-Phe-Ala-OBz

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Phe-Ala-OBz

There total 3 articles about Boc-Phe-Ala-OBz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + N-Alloc-alanine benzylester → Boc-Phe-Ala-OBz (74257-68-4)

Guidance literature:

N-tert-butoxycarbonyl-L-phenylalanine; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 2h;

N-Alloc-alanine benzylester; With 1,4-diaza-bicyclo[2.2.2]octane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 0.166667h;

DOI:10.1016/S0040-4039(01)01453-8

Reference yield: 75.0%

H-Ala-OBzl (17831-01-5) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Boc-Phe-Ala-OBz (74257-68-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1039/c39930000237

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + L-alanine benzyl ester p-toluenesulfonate (42854-62-6) → Boc-Phe-Ala-OBz (74257-68-4)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 26h;

DOI:10.1002/cbic.201300032

upstream raw materials:

H-Ala-OBzl

N-tert-butoxycarbonyl-L-phenylalanine

L-alanine benzyl ester p-toluenesulfonate

Downstream raw materials:

H-Phe-Ala-OBn