{(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester
• CAS No.: 78569-26-3
• Molecular Formula: C₂₃H₃₃N₃O₄S₂
• Molecular Weight: 479.665

Synonyms:{(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

Chemical Property of {(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

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Technology Process of {(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester

There total 3 articles about {(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiazolidine-2-thione (134469-06-0) + Z-L-Leu-D-Ileu-OH (78569-25-2) → {(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester (78569-26-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 5h;

DOI:10.1246/cl.1981.463

Reference yield:

Z-Leu-OH (2018-66-8) → {(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester (78569-26-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 5 h / 0 °C

2: 89 percent / Et₃N / H₂O; tetrahydrofuran / Ambient temperature

3: dicyclohexylcarbodiimide / CH₂Cl₂ / 5 h / 0 °C

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1246/cl.1981.463

Reference yield:

3-(N-benzyloxycarbonyl-L-leucyl)-1,3-thiazolidine-2-thione (78569-22-9) → {(S)-3-Methyl-1-[(1R,2R)-2-methyl-1-(2-thioxo-thiazolidine-3-carbonyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester (78569-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Et₃N / H₂O; tetrahydrofuran / Ambient temperature

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 5 h / 0 °C

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1246/cl.1981.463

upstream raw materials:

thiazolidine-2-thione

Z-L-Leu-D-Ileu-OH

Z-Leu-OH

3-(N-benzyloxycarbonyl-L-leucyl)-1,3-thiazolidine-2-thione

Downstream raw materials:

Z-L-Leu-D-Ileu-L-(S-Bzl)Cys-OH

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