(3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:(3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1462969-02-3
Molecular Formula:C₂₂H₂₈F₃NO₆
Molecular Weight:459.463
Hs Code.:

Synonyms:(3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 6 articles about (3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 1462969-01-2
ethyl (S)-2-((3R,5R)-3-hydroxy-5-isopropyl-2-oxopyrrolidin-1-yl)propanoate

: 1462969-02-3
(3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2013.08.084

Reference yield:

: 1462968-79-1
(S,Z)-N-(1-ethoxy-1-oxopropan-2-yl)-1-phenylmethanimine oxide

: 1462969-02-3
(3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; acetic acid; hydroxylamine hydrochloride / methanol / 16 h / Reflux

2: magnesium sulfate / 4 h / 20 °C

3: toluene / 16 h / 80 °C / Sealed tube

4: ethanol / 48 h / 20 °C / 76005.1 Torr

5: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h / 20 °C

With dmap; hydroxylamine hydrochloride; magnesium sulfate; acetic acid; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.08.084

Reference yield:

: 60855-77-8
ethyl N-benzylidenealaninate

: 1462969-02-3
(3R,5R)-1-((S)-1-ethoxy-1-oxopropan-2-yl)-5-isopropyl-2-oxopyrrolidin-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: urea hydrogen peroxide adduct; magnesium sulfate; methyltrioxorhenium(VII) / methanol / 7 h / 20 °C

2: sodium hydroxide; acetic acid; hydroxylamine hydrochloride / methanol / 16 h / Reflux

3: magnesium sulfate / 4 h / 20 °C

4: toluene / 16 h / 80 °C / Sealed tube

5: ethanol / 48 h / 20 °C / 76005.1 Torr

6: dicyclohexyl-carbodiimide; dmap / dichloromethane / 12 h / 20 °C

With dmap; hydroxylamine hydrochloride; urea hydrogen peroxide adduct; methyltrioxorhenium(VII); magnesium sulfate; acetic acid; dicyclohexyl-carbodiimide; sodium hydroxide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.08.084