(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone

Base Information

Chemical Name:(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone
CAS No.:1015071-32-5
Molecular Formula:C₃₀H₄₆O₃Si₂
Molecular Weight:510.864
Hs Code.:

Synonyms:(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone

Suppliers and Price of (2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone

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Technology Process of (2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone

There total 2 articles about (2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1015071-31-4
5-(tert-butyldimethylsiloxy)-4-hydroxy-2-methylcycloheptanone

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1015071-32-5
(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol8001333

Reference yield:

: 1015071-29-0
(3S,5R,1'R)-5-[1-(tert-butyldimethylsiloxy)-3-iodopropyl]-3-methyldihydrofuran-2-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1015071-32-5
(2S,4R,5R)-5-(tert-butyldimethylsiloxy)-4-(tert-butyldiphenylsiloxy)-2-methylcycloheptanone

Guidance literature:: (3S,5R,1'R)-5-[1-(tert-butyldimethylsiloxy)-3-iodopropyl]-3-methyldihydrofuran-2-one; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

tert-butylchlorodiphenylsilane; With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.tet.2010.08.061