Technology Process of C43H51N7O10S
There total 5 articles about C43H51N7O10S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-ethyl-10-hydroxycamptothecin;
With
pyridine; potassium tert-butylate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
for 0.25h;
Cooling with ice;
Inert atmosphere;
O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 4 - 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jm401644v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran / 1 h
2.1: chloro-trimethyl-silane / toluene / 24 h / 50 °C / Inert atmosphere
3.1: pyridine; potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / Cooling with ice; Inert atmosphere
3.2: 1 h / 4 - 20 °C / Inert atmosphere
With
pyridine; chloro-trimethyl-silane; potassium tert-butylate; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm401644v
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: chloro-trimethyl-silane / toluene / 24 h / 50 °C / Inert atmosphere
2.1: pyridine; potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / Cooling with ice; Inert atmosphere
2.2: 1 h / 4 - 20 °C / Inert atmosphere
With
pyridine; chloro-trimethyl-silane; potassium tert-butylate;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm401644v
![O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate](/Databaselist/images/loading.webp)
