O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate

Base Information

• Chemical Name: O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate
• CAS No.: 1346434-63-6
• Molecular Formula: C₂₁H₃₂ClN₅O₅S
• Molecular Weight: 502.035
• Mol file: 1346434-63-6.mol

Synonyms:O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate

Chemical Property of O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate

There total 5 articles about O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + O-[7-azido-1-(methylsulfonyl)-2-heptyl]-N-[4’-(diethylcarbamoyl)phenyl]carbamate (1346434-58-9) → O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate (1346434-63-6)

Guidance literature:

With chloro-trimethyl-silane; In toluene; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm401644v

Reference yield:

1-(methylsulfonyl)-7-azido-2-heptanol (1346434-30-7) → O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate (1346434-63-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / tetrahydrofuran / 0.17 h / 20 °C

2: triethylamine / tetrahydrofuran / 1 h

3: chloro-trimethyl-silane / toluene / 24 h / 50 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1021/jm401644v

Reference yield:

1-(methanesulfonyl)-7-azido-2-heptyl chloroformate (1346434-41-0) → O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-chloromethyl carbamate (1346434-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h

2: chloro-trimethyl-silane / toluene / 24 h / 50 °C / Inert atmosphere

With chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1021/jm401644v

upstream raw materials:

1-(methanesulfonyl)-7-azido-2-heptyl chloroformate

1-(methylsulfonyl)-7-azido-2-heptanol

4-amino-N,N-diethylbenzamide

formaldehyd

Downstream raw materials:

O-[1-(methanesulfonyl)-7-azido-2-heptyl]-N-[4-(diethylcarboxamido)phenyl]-N-methoxymethyl carbamate

C₄₃H₅₁N₇O₁₀S