ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate

Base Information

Chemical Name:ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate
CAS No.:1400635-22-4
Molecular Formula:C₂₀H₁₉N₅O₄S₂
Molecular Weight:457.534
Hs Code.:

Synonyms:ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate

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Chemical Property of ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate

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Technology Process of ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate

There total 5 articles about ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1400635-21-3
5-benzyl-3-methyl-4-oxo-8-thioxo-4,5,7,8-tetrahydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidine-2-carboxamide

: 105-36-2
ethyl bromoacetate

: 1400635-22-4
ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate

Guidance literature:: 5-benzyl-3-methyl-4-oxo-8-thioxo-4,5,7,8-tetrahydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidine-2-carboxamide; ethyl bromoacetate; In ethanol; for 9h; Reflux;

With sodium acetate; for 0.5h; Heating;
DOI:10.1016/j.ejmech.2012.07.007

Reference yield:

: 1400635-09-7
3-benzyl-5-methyl-2-(methylsulfanyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide

: 1400635-22-4
ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 3 h / Reflux

2.1: sodium acetate; potassium hydroxide / ethanol / 12 h / Reflux

3.1: ethanol / 9 h / Reflux

3.2: 0.5 h / Heating

With sodium acetate; hydrazine hydrate; potassium hydroxide; In ethanol;
DOI:10.1016/j.ejmech.2012.07.007

Reference yield:

: 43028-63-3
ethyl 2-amino-5-carbamoyl-4-methylthiophene-3-carboxylate

: 1400635-22-4
ethyl [(5-benzyl-2-carbamoyl-3-methyl-4-oxo-4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-8-yl)sulfanyl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 15 h / Reflux

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: hydrazine hydrate / ethanol / 3 h / Reflux

4.1: sodium acetate; potassium hydroxide / ethanol / 12 h / Reflux

5.1: ethanol / 9 h / Reflux

5.2: 0.5 h / Heating

With sodium acetate; potassium carbonate; hydrazine hydrate; potassium hydroxide; In ethanol; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2012.07.007