3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate

Base Information

Chemical Name:3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate
CAS No.:1318792-68-5
Molecular Formula:C₈H₈O₃*C₂₃H₂₈N₆O₂
Molecular Weight:572.664
Hs Code.:

Synonyms:3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate

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Chemical Property of 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate

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Technology Process of 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate

There total 17 articles about 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318792-63-0
AZD₇₉₂₉

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

: 1318792-68-5
3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate

Guidance literature:: In isopropyl alcohol; at 17 - 25 ℃; for 120h; Inert atmosphere;

Reference yield:

: 6966-01-4
methyl 3-amino-6-bromopyrazine-2-carboxylate

: 1318792-68-5
3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / methanol / 3 h / 50 °C / Inert atmosphere

1.2: 17 - 25 °C / pH 3 / Inert atmosphere

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 17 - 25 °C / Inert atmosphere

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 90 °C / Inert atmosphere

4.1: hydrogen fluoride / tetrahydrofuran / 3 h / 17 - 25 °C / Inert atmosphere

4.2: 17 - 25 °C / pH 10 - 11 / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 25 °C / Inert atmosphere

6.1: potassium carbonate / acetonitrile / 90 °C / Inert atmosphere

7.1: isopropyl alcohol / 120 h / 17 - 25 °C / Inert atmosphere

With hydrogen fluoride; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 25574-11-2
3-(4-bromophenyl)propanol

: 1318792-68-5
3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-DL-mandelate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane / 17 - 25 °C / Inert atmosphere

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 90 °C / Inert atmosphere

4.1: hydrogen fluoride / tetrahydrofuran / 3 h / 17 - 25 °C / Inert atmosphere

4.2: 17 - 25 °C / pH 10 - 11 / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 25 °C / Inert atmosphere

6.1: potassium carbonate / acetonitrile / 90 °C / Inert atmosphere

7.1: isopropyl alcohol / 120 h / 17 - 25 °C / Inert atmosphere

With dmap; hydrogen fluoride; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; acetonitrile;