(S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol

Base Information

Chemical Name:(S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol
CAS No.:189059-60-7
Molecular Formula:C₂₀H₂₆ClNO₄
Molecular Weight:379.884
Hs Code.:

Synonyms:(S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol

Suppliers and Price of (S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol

There total 4 articles about (S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 597-31-9
2,2-dimethyl-3-hydroxypropionaldehyde

: 189059-58-3
(-)-2-amino-5-chloro-α-(2,3-dimethoxyphenyl)benzyl alcohol

: 189059-60-7
(S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol

Guidance literature:: 2,2-dimethyl-3-hydroxypropionaldehyde; (-)-2-amino-5-chloro-α-(2,3-dimethoxyphenyl)benzyl alcohol; hydrogenchloride; In toluene; at 25 ℃; for 0.5h;

With hydrogenchloride; sodium tetrahydroborate; In N,N-dimethyl acetamide; toluene; at 5 ℃; for 1h;

With sodium hydroxide; In methanol; N,N-dimethyl acetamide; water; toluene; at 10 - 20 ℃; for 1h;

Reference yield:

: 3-{(E)-4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenylimino}-2,2-dimethyl-propan-1-ol

: 189059-60-7
(S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol

Guidance literature:: With sodium cyanoborohydride; In methanol; at 60 ℃; for 2h;
DOI:10.1021/jm020234o

Reference yield:

: 597-31-9
2,2-dimethyl-3-hydroxypropionaldehyde

: 189059-60-7
(S)-5-chloro-α-(2,3-dimethoxyphenyl)-2-(3-hydroxy-2,2-dimethylpropyl)aminobenzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: AcOH / methanol / 1 h / 60 °C

2: NaBH₃CN / methanol / 2 h / 60 °C

With sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1021/jm020234o