acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester

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Chemical Name:acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester
CAS No.:919350-79-1
Molecular Formula:C₂₆H₃₄N₂O₁₂
Molecular Weight:566.562
Hs Code.:

Synonyms:acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester

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Chemical Property of acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester

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Technology Process of acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester

There total 5 articles about acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 919350-78-0
4-{2-hydroxy-2-[4-(3,4,5-triacetoxy-6-acetoxymethyltetrahydropyran-2-yloxy)phenyl]acetyl}piperazine-1-carboxylic acid benzyl ester

: 919350-79-1
acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/ja0657307

Reference yield:

: 78701-22-1
acetoxy-(4-acetoxyphenyl)acetic acid

: 919350-79-1
acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; Et₃N / CH₂Cl₂ / 20 °C

2: 77 percent / aq. NaOH / methanol / 3 h / 0 °C

3: 37 percent / Cs₂CO₃ / dimethylformamide / 3 h / 20 °C

4: 97 percent / H₂; AcOH / Pd/C / ethanol

With sodium hydroxide; hydrogen; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0657307

Reference yield:

: 919350-76-8
4-[2-acetoxy-2-(4-acetoxyphenyl)acetyl]piperazine-1-carboxylic acid benzyl ester

: 919350-79-1
acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[4-(1-hydroxy-2-oxo-2-piperazin-1-ylethyl)phenoxy]tetrahydropyran-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / aq. NaOH / methanol / 3 h / 0 °C

2: 37 percent / Cs₂CO₃ / dimethylformamide / 3 h / 20 °C

3: 97 percent / H₂; AcOH / Pd/C / ethanol

With sodium hydroxide; hydrogen; caesium carbonate; acetic acid; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja0657307