78701-22-1Relevant academic research and scientific papers
Fluorescent probe for covalently connecting labeled cells and method for tracking labeled cells
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Paragraph 0037-0038, (2019/04/30)
The invention discloses a fluorescence probe for covalently connecting labeled cells and a method for tracking labeled cells, and relates to a cell fluorescence probe, wherein the fluorescent probe for covalently connecting labeled cells consists of a cov
A covalent reporter of β-lactamase activity for fluorescent imaging and rapid screening of antibiotic-resistant bacteria
Shao, Qing,Zheng, Yan,Dong, Xueming,Tang, Kai,Yan, Xiaomei,Xing, Bengang
supporting information, p. 10903 - 10910 (2013/09/02)
Bacterial resistance to antibiotics poses a great clinical challenge in fighting serious infectious diseases due to complicated resistant mechanisms and time-consuming testing methods. Chemical reaction-directed covalent labeling of resistance-associated
Nucleic-acid triggered release of molecules
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Page/Page column 15, (2009/10/06)
It is an object of the present invention to provide a method for highly selectively releasing a molecule of interest such as an agent at a desired site while suppressing the influence of catabolic enzymes existing in vivo. The present invention provides a
Design and synthesis of an enzyme activity-based labeling molecule with fluorescence spectral change
Komatsu, Toru,Kikuchi, Kazuya,Takakusa, Hideo,Hanaoka, Kenjiro,Ueno, Tasuku,Kamiya, Mako,Urano, Yasuteru,Nagano, Tetsuo
, p. 15946 - 15947 (2007/10/03)
Methods of covalent labeling of a specific tag protein with small-molecular dyes play an important role in studying dynamic behaviors of proteins in living cells. On the basis of quinone methide chemistry, we designed and synthesized a β-galactosidase labeling probe, CMFβ-gal, which shows a fluorescence wavelength change accompanying the labeling reaction, owing to fluorescence resonance energy transfer (FRET). Since the FRET efficiency changes accompanying the labeling reaction, fluorescence of labeled protein can be observed separately from that of the unreacted probe, so immediate detection of the target protein is possible. This is the first report of a protein labeling probe which features a change of fluorescence wavelength upon reaction, allowing the labeled protein to be detected even in the presence of unreacted probe. Copyright
Phenyl alpha acyloxyalkanoic acids, derivatives and their therapeutic use
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, (2008/06/13)
Therapeutic as well as preventative measures to improve the cosmetic conditions or to alleviate the symptoms of dermatologic disorders with phenyl alpha acyloxyalkanoic acids and derivatives is disclosed. The cosmetic conditions and dermatologic disorders
