4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

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Chemical Name:4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole
CAS No.:757189-24-5
Molecular Formula:C₂₇H₂₇N₃O₃
Molecular Weight:441.53
Hs Code.:

Synonyms:4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

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Chemical Property of 4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

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Technology Process of 4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

There total 3 articles about 4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 123-75-1
pyrrolidine

: 757189-06-3
methyl 4'-(3-benzyloxy-4-methoxyphenyl)-1'H-1,3'-bipyrrole-2'-carboxylate

: 757189-24-5
4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

Guidance literature:: Heating;
DOI:10.1016/j.bmc.2006.09.022

Reference yield:

: 3-amino-4-(3-benzyloxy-4-methoxy-phenyl)-1H-pyrrole-2-carboxylic acid methyl ester

: 757189-24-5
4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 4-chloropyridine hydrochloride / dioxane / 100 °C

2: 68 percent / Heating

With 4-chlorpyridine hydrochloride; In 1,4-dioxane; 1: Clauson-Kaas reaction;
DOI:10.1016/j.bmc.2006.09.022

Reference yield:

: 3-amino-4-(3-benzyloxy-4-methoxy-phenyl)-1H-pyrrole-2-carboxylic acid methyl ester

: 757189-24-5
4'-(3-benzyloxy-4-methoxyphenyl)-2'-(pyrrolidin-1-ylcarbonyl)-1'H-1,3'-bipyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 4-chloropyridine hydrochloride / dioxane / 1.5 h / 100 °C

2: 12 h / 87 °C

With 4-chlorpyridine hydrochloride; In 1,4-dioxane; 1: Clauson-Kaas and Zdenek reaction;
DOI:10.1016/j.tetlet.2004.06.047