(4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone

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Chemical Name:(4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone
CAS No.:1270979-86-6
Molecular Formula:C₂₄H₂₆FN₇O
Molecular Weight:447.515
Hs Code.:

Synonyms:(4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone

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Chemical Property of (4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone

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Technology Process of (4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone

There total 5 articles about (4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1270981-86-6
4-{1-[1-(piperazin-1-ylmethyl)propyl]-1H-pyrazol-4-yl}-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

: 403-43-0
4-fluorobenzoyl chloride

: 1270979-86-6
(4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone

Guidance literature:: 4-{1-[1-(piperazin-1-ylmethyl)propyl]-1H-pyrazol-4-yl}-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine; 4-fluorobenzoyl chloride; In dichloromethane; for 2h;

With trifluoroacetic acid; In dichloromethane; for 1h;

With ethylenediamine; In methanol; for 2h;

Reference yield:

: 941685-27-4
4-(1H-pyrazol-4-yl)-7-((2-trimethylsilanylethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1270979-86-6
(4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 4.5 h

2.1: diisobutylaluminium hydride / toluene / -78 - -55 °C

3.1: dichloromethane / 1.6 h

3.2: 1 h

4.1: hydrogenchloride / 1,4-dioxane / 1 h

5.1: dichloromethane / 2 h

5.2: 1 h

5.3: 2 h

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1270981-82-2
ethyl 2-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butanoate

: 1270979-86-6
(4-(2-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)butyl)piperazin-1-yl)(4-fluorophenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / toluene / -78 - -55 °C

2.1: dichloromethane / 1.6 h

2.2: 1 h

3.1: hydrogenchloride / 1,4-dioxane / 1 h

4.1: dichloromethane / 2 h

4.2: 1 h

4.3: 2 h

With hydrogenchloride; diisobutylaluminium hydride; In 1,4-dioxane; dichloromethane; toluene;