4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid

Base Information

Chemical Name:4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid
CAS No.:1260224-89-2
Molecular Formula:C₂₆H₂₂ClNO₄
Molecular Weight:447.918
Hs Code.:

Synonyms:4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid

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Chemical Property of 4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid

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Technology Process of 4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid

There total 7 articles about 4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1260225-00-0
C₂₇H₂₄ClNO₄

: 1260224-89-2
4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 80 ℃;
DOI:10.1021/jm1012165

Reference yield:

: 27550-59-0
4-hydroxyphthalic anhydride

: 1260224-89-2
4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 12 h / 110 °C / Molecular sieve; Inert atmosphere

2: acetic acid; zinc / 0.08 h / Reflux; Inert atmosphere

3: potassium carbonate / acetone / 60 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 80 °C

With water; potassium carbonate; acetic acid; lithium hydroxide; zinc; In tetrahydrofuran; acetone; toluene;
DOI:10.1021/jm1012165

Reference yield:

: 1183393-79-4
4-chloro-3'-methylbiphenyl-3-carboxylic acid

: 1260224-89-2
4-chloro-3'-((2-cyclobutyl-1-oxoisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 1 h / 50 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / Reflux; Inert atmosphere

3: potassium carbonate / acetone / 60 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 80 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; tetrachloromethane; acetone;
DOI:10.1021/jm1012165