4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide

Base Information

• Chemical Name: 4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide
• CAS No.: 1312543-45-5
• Molecular Formula: C₂₄H₂₄N₄O₂S
• Molecular Weight: 432.546
• Mol file: 1312543-45-5.mol

Synonyms:4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide

Chemical Property of 4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide

There total 5 articles about 4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-tert-butylphenylamino)benzo[d]thiazol-5-ol (850714-29-3) + 4-chloro-N-methylpicolinamide (220000-87-3) → 4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide (1312543-45-5)

Guidance literature:

With potassium hexamethylsilazane; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

DOI:10.1016/j.bmcl.2011.04.023

Reference yield:

N-(3-tert-butylphenyl)-5-methoxybenzo[d]thiazol-2-amine (1312543-47-7) → 4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide (1312543-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide / 0.1 h / 150 °C / Microwave irradiation

2: potassium hexamethylsilazane; potassium carbonate / N,N-dimethyl-formamide / 90 °C

With hydrogen bromide; potassium hexamethylsilazane; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.04.023

Reference yield:

2-bromo-5-methoxybenzothiazole (214337-39-0) → 4-(2-(3-tert-butyl phenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide (1312543-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 220 °C / Microwave irradiation

2: hydrogen bromide / 0.1 h / 150 °C / Microwave irradiation

3: potassium hexamethylsilazane; potassium carbonate / N,N-dimethyl-formamide / 90 °C

With hydrogen bromide; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.04.023

upstream raw materials:

2-(3-tert-butylphenylamino)benzo[d]thiazol-5-ol

4-chloro-N-methylpicolinamide

N-(3-tert-butylphenyl)-5-methoxybenzo[d]thiazol-2-amine

3-tert-butylaniline