850714-29-3Relevant articles and documents
Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors
Ramurthy, Savithri,Aikawa, Mina,Amiri, Payman,Costales, Abran,Hashash, Ahmad,Jansen, Johanna M.,Lin, Song,Ma, Sylvia,Renhowe, Paul A.,Shafer, Cynthia M.,Subramanian, Sharadha,Sung, Leonard,Verhagen, Joelle
, p. 3286 - 3289 (2011/06/24)
Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan-Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic p