ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate

Base Information

Chemical Name:ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate
CAS No.:883046-98-8
Molecular Formula:C₂₅H₂₁FO₃
Molecular Weight:388.438
Hs Code.:

Synonyms:ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate

Suppliers and Price of ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate

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Technology Process of ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate

There total 3 articles about ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 104765-79-9
(2E)-1-(2-naphthyl)-3-(4-fluorophenyl)-2-propen-1-one

: 141-97-9
ethyl acetoacetate

: 883046-98-8
ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate

Guidance literature:: With sodium ethanolate; In ethanol; at 70 - 80 ℃; for 1h;
DOI:10.3109/14756361003689856

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 93-08-3
methyl 2-naphthyl ketone

: 883046-98-8
ethyl 6-(4-fluorophenyl)-4-(naphthalen-2-yl)-2-oxocyclohex-3-enecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 1 h / 20 °C

2: sodium ethanolate / ethanol / 1 h / 70 - 80 °C

With sodium ethanolate; sodium hydroxide; In ethanol; 1: Claisen-Schmidt condensation;
DOI:10.3109/14756361003689856