2-BROMO-3,4-DIFLUOROBENZALDEHYDE

Base Information

• Chemical Name: 2-BROMO-3,4-DIFLUOROBENZALDEHYDE
• CAS No.: 1578156-21-4
• Molecular Formula: C₇H₃BrF₂O
• Molecular Weight: 221.001
• Hs Code.: 2913000090
• Mol file: 1578156-21-4.mol

Synonyms:2-bromo-3,4-difluoro-benzaldehyde

Chemical Property of 2-BROMO-3,4-DIFLUOROBENZALDEHYDE

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3,4-difluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-BROMO-3,4-DIFLUOROBENZALDEHYDE

There total 2 articles about 2-BROMO-3,4-DIFLUOROBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-bromo-3,4-difluoro-N-methoxy-N-methyl-benzamide → 2-bromo-3,4-difluoro-benzaldehyde (1578156-21-4)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

2-bromo-3,4-difluorobenzoic acid (170108-05-1) → 2-bromo-3,4-difluoro-benzaldehyde (1578156-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With borane-THF; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

Reference yield:

2-bromo-3,4-difluoro-benzaldehyde (1578156-21-4) → C16H12BrF2N3O2S + C16H12BrF2N3O2S

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate / 2,2,2-trifluoroethanol / 16 h / Reflux; Inert atmosphere

2: Daicel Chiralpak IC, 30 mm × 250 mm, 5 μm / Resolution of racemate

With potassium acetate; In 2,2,2-trifluoroethanol;

DOI:10.1021/acs.jmedchem.7b00083

upstream raw materials:

2-bromo-3,4-difluorobenzoic acid

Refernces

• 1、 -. "HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS". . . Retrieved 2019/01/17.
• 2、 -. "Novel 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection". . . Retrieved 2015/02/19.