2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone

Base Information

• Chemical Name: 2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone
• CAS No.: 359826-10-1
• Molecular Formula: C₂₈H₂₆ClF₂N₅O₂
• Molecular Weight: 537.997
• Mol file: 359826-10-1.mol

Synonyms:2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone

Chemical Property of 2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone

There total 1 articles about 2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-[4-(2-methyl-5-chlorophenyl)-1-piperazinyl]phenyl-1-3-(2H,4H)-1,2,4-triazolone (359826-09-8) + 2-chloro-1-(2,4-difluorophenyl)propan-1-one (126917-43-9,135133-19-6,138457-39-3) → 2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone (359826-10-1)

Guidance literature:

4-[4-(2-methyl-5-chlorophenyl)-1-piperazinyl]phenyl-1-3-(2H,4H)-1,2,4-triazolone; With sodium hydride; In dimethyl sulfoxide; at 25 - 30 ℃; for 1h;

2-chloro-1-(2,4-difluorophenyl)propan-1-one; In dimethyl sulfoxide; at 15 - 60 ℃; for 5 - 6h;

Reference yield: 100.0%

2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone (359826-10-1) + trimethylsulfoxonium iodide (1774-47-6) → 2-[1-(R/S)-methyl-2-(2'-4'-difluorophenyl)-2,3-epoxypropyl]-4-{4-[4-(5-chloro-2-methylphenyl)piperazinyl]phenyl}-3-(2H,4H)-1,2,4-triazolone

Guidance literature:

trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; at 15 - 30 ℃; for 1h;

2-{4-[4-[4-(2-methyl-5-chlorophenyl)piperazinyl]phenyl]-(2H,4H)-1,2,4-triazol-3-one-2-yl}-2(R/S)-methyl-2,4-difluoroacetophenone; In dimethyl sulfoxide; at 25 - 90 ℃; for 1h;

upstream raw materials:

4-[4-(2-methyl-5-chlorophenyl)-1-piperazinyl]phenyl-1-3-(2H,4H)-1,2,4-triazolone

2-chloro-1-(2,4-difluorophenyl)propan-1-one

Refernces