benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate

Base Information

Chemical Name:benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate
CAS No.:1258408-28-4
Molecular Formula:C₂₈H₂₇N₃O₄S
Molecular Weight:501.606
Hs Code.:

Synonyms:benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate

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Chemical Property of benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate

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Technology Process of benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate

There total 7 articles about benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1258408-26-2
benzyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-piperazine-1-carboxylate

: 1258408-28-4
benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate

Guidance literature:: benzyl 4-[3-formyl-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-piperazine-1-carboxylate; With toluene-4-sulfonic acid hydrazide; In toluene; at 20 ℃; for 3h; Sonographic reaction;

With sodium hydride; In toluene; at 130 ℃; for 0.2h; Microwave irradiation; Inert atmosphere; Sealed tube;

With sodium hydrogencarbonate; In ethyl acetate; toluene;

Reference yield:

: C₃₅H₃₅N₅O₆S₂

: 1258408-28-4
benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate

Guidance literature:: With sodium hydride; In toluene; at 130 ℃; for 0.2h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.tet.2010.09.023

Reference yield:

: 255714-24-0
4-piperazin-1-yl-1H-indole dihydrochloride

: 1258408-28-4
benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: trichlorophosphate / 3.75 h / 0 - 20 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene; water / 0.75 h / 20 °C

4.1: toluene-4-sulfonic acid hydrazide / toluene / 3 h / 20 °C / Sonographic reaction

4.2: 0.2 h / 130 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With N-benzyl-N,N,N-triethylammonium chloride; toluene-4-sulfonic acid hydrazide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water; toluene;