benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate

Base Information

Chemical Name:benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate
CAS No.:1258408-34-2
Molecular Formula:C₂₁H₂₁N₃O₂
Molecular Weight:347.417
Hs Code.:

Synonyms:benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate

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Chemical Property of benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate

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Technology Process of benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate

There total 6 articles about benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1258408-28-4
benzyl 4-(toluene-4-sulfonyl)-4,6,6a,7,9,10-hexahydro-4,8,10a-triaza-acephenanthrylene-8-carboxylate

: 1258408-34-2
benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate

Guidance literature:: With methanol; magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Sonication;
DOI:10.1016/j.tet.2010.09.023

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1258408-34-2
benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: trichlorophosphate / 3.75 h / 0 - 20 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene; water / 0.75 h / 20 °C

4.1: toluene-4-sulfonic acid hydrazide / toluene / 3 h / 20 °C / Sonographic reaction

4.2: 0.2 h / 130 °C / Microwave irradiation; Inert atmosphere; Sealed tube

5.1: magnesium / methanol / 0.5 h / 0 °C / Sonographic reaction

With N-benzyl-N,N,N-triethylammonium chloride; magnesium; toluene-4-sulfonic acid hydrazide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 255714-24-0
4-piperazin-1-yl-1H-indole dihydrochloride

: 1258408-34-2
benzyl 6a,7,9,10-tetrahydro-4H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinoline-8(6H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: trichlorophosphate / 3.75 h / 0 - 20 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene; water / 0.75 h / 20 °C

4.1: toluene-4-sulfonic acid hydrazide / toluene / 3 h / 20 °C / Sonographic reaction

4.2: 0.2 h / 130 °C / Microwave irradiation; Inert atmosphere; Sealed tube

5.1: magnesium / methanol / 0.5 h / 0 °C / Sonographic reaction

With N-benzyl-N,N,N-triethylammonium chloride; magnesium; toluene-4-sulfonic acid hydrazide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; water; toluene;