2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate

Base Information

Chemical Name:2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate
CAS No.:1370447-52-1
Molecular Formula:C₂₂H₂₅ClN₄O₅S
Molecular Weight:492.983
Hs Code.:

Synonyms:2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate

There total 6 articles about 2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370447-26-9
2-[3-(3-chlorophenyl)-1-(4-ethenylphenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

: 1370447-52-1
2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

1.2: 20 °C

2.1: triethylamine / chloroform / 20 °C / Cooling with ice

With borane-THF; triethylamine; In tetrahydrofuran; chloroform;

Reference yield:

: 62123-73-3
ethyl 2‐(3‐chlorophenyl)‐2‐oxoacetate

: 1370447-52-1
2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; water / methanol; tetrahydrofuran / 20 °C / Cooling with ice

2.1: hydrogenchloride / water / 72 h

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 8 h / Inert atmosphere; Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 5 h / 100 °C / Inert atmosphere

6.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

6.2: 20 °C

7.1: triethylamine / chloroform / 20 °C / Cooling with ice

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1370447-13-4
2-[1-(4-bromophenyl)-3-(3-chlorophenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

: 1370447-52-1
2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 5 h / 100 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

2.2: 20 °C

3.1: triethylamine / chloroform / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; triethylamine; In tetrahydrofuran; chloroform; toluene;