2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate

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Chemical Name:2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate
CAS No.:1370446-81-3
Molecular Formula:CH₂O₂*C₂₆H₃₂FN₅O₃
Molecular Weight:527.596
Hs Code.:

Synonyms:2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate

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Chemical Property of 2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate

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Technology Process of 2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate

There total 8 articles about 2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 64-18-6
formic acid

: 1370447-52-1
2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate

: 1370446-81-3
2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate

Guidance literature:: pyrrolidine; 2-(4-{3-(3-chlorophenyl)-5-oxo-4-[2-oxo-2-(propan-2-ylamino)ethyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}phenyl)ethyl methanesulfonate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃;

formic acid; In water; acetonitrile;

Reference yield:

: 1370447-13-4
2-[1-(4-bromophenyl)-3-(3-chlorophenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

: 1370446-81-3
2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 5 h / 100 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

2.2: 20 °C

3.1: triethylamine / chloroform / 20 °C / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; toluene; acetonitrile;

Reference yield:

: 1370447-26-9
2-[3-(3-chlorophenyl)-1-(4-ethenylphenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

: 1370446-81-3
2-[3-(4-fluoro-3-methoxyphenyl)-5-oxo-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide formate

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

1.2: 20 °C

2.1: triethylamine / chloroform / 20 °C / Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

With borane-THF; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; acetonitrile;