Flavin mononucleotide

Base Information

• Chemical Name: Flavin mononucleotide
• CAS No.: 146-17-8
• Molecular Formula: C17H21 N4 O9 P
• Molecular Weight: 456.349
• Hs Code.: HOSPHATE SODIUM PRODUCT IDENTIFICATION
• European Community (EC) Number: 205-664-7
• UNII: 7N464URE7E
• DSSTox Substance ID: DTXSID8023559
• Nikkaji Number: J30.175B
• Wikipedia: Flavin_mononucleotide
• Wikidata: Q376061
• NCI Thesaurus Code: C61925
• RXCUI: 1925821
• Metabolomics Workbench ID: 37845
• ChEMBL ID: CHEMBL1201794
• Mol file: 146-17-8.mol

Synonyms:5'-Monophosphate, Riboflavin;5'-Phosphate, Riboflavin;Flavin Mononucleotide;Flavin Mononucleotide Disodium Salt;Flavin Mononucleotide Monosodium Salt;Flavin Mononucleotide Monosodium Salt, Dihydrate;Flavin Mononucleotide Sodium Salt;FMN;Mononucleotide, Flavin;Mononucleotide, Riboflavin;Phosphate, Sodium Riboflavin;Riboflavin 5' Monophosphate;Riboflavin 5' Phosphate;Riboflavin 5'-Monophosphate;Riboflavin 5'-Phosphate;Riboflavin Mononucleotide;Riboflavin Phosphate, Sodium;Sodium Riboflavin Phosphate

Chemical Property of Flavin mononucleotide

Chemical Property:

• Appearance/Colour: yellow to orange crystalline powder
• Melting Point: 195 °C
• Boiling Point: °Cat760mmHg
• PKA: 1.84±0.10(Predicted)
• Flash Point: °C
• PSA: 217.90000
• Density: 1.83g/cm³
• LogP: -1.55820
• XLogP3: -2.6
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 7
• Exact Mass: 456.10461526
• Heavy Atom Count: 31
• Complexity: 844

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s): Not regulated UN NO.
• Hazard Codes: Not regulated UN NO.

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Vitamins and Derivatives
• Canonical SMILES: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(COP(=O)(O)O)O)O)O
• Isomeric SMILES: CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@@H]([C@@H](COP(=O)(O)O)O)O)O
• Recent ClinicalTrials: Epi-On Corneal Crosslinking for Keratoconus
• Recent EU Clinical Trials: 'Randomized clinical trial with two parallel groups, double-blind, placebo-controlled trial to investigate whether administration of CBG000592 (riboflavin/vitamin B2) in patients with acute ischemic stroke causes a reduction of glutamate-mediated excitotoxicity'
• Uses: One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor) Riboflavine 5’-Phosphate is an intermediate in the synthesis of Riboflavin-4''-phosphate (R415010), a phosphate ester of Riboflavin (R414995) which is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).

Technology Process of Flavin mononucleotide

There total 24 articles about Flavin mononucleotide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

water (7732-18-5) + flavin adenine dinucleotide (146-14-5,887565-61-9) → lumiflavin (1088-56-8) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1) + Flavin mononucleotide (146-17-8,69680-01-9) + riboflavin (83-88-5,42880-33-1)

Guidance literature:

vom pH 3-9;

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + flavin adenine dinucleotide (146-14-5,887565-61-9) → lumiflavin (1088-56-8) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1) + Flavin mononucleotide (146-17-8,69680-01-9) + riboflavin (83-88-5,42880-33-1)

Guidance literature:

Adenin, O⁵-Phosphono-D-ribose und H₃PO₄;

Reference yield:

Phosphoric acid mono-[(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-10-yl)-2,3,4-trihydroxy-pentyl] ester; compound with 9H-β-carboline → betacarboline (244-63-3) + Flavin mononucleotide (146-17-8,69680-01-9)

Guidance literature:

With phosphate buffer pH 6; In water; at 5 - 25 ℃; Equilibrium constant; investigated with absorption spectroscopy;

DOI:10.1016/0584-8539(93)80248-9

upstream raw materials:

1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-5-hydroxypentane-2,3,4-triyl triacetate

pyrocatechol cyclophosphoric acid

riboflavin

ethyl phosphodichloridite

Downstream raw materials:

lumiflavin

riboflavin

flavin mononucleotide

flavin adenine dinucleotide

Refernces

• 1、 Codoner, Armando,Medina, Piedad,Jover, Enrique,Sanchez, Jesus A.. "Spectroscopic study of molecular associations between FMN and β-carbolines". . p. 1793 - 1800. Retrieved 1993.
• 2、 Richter, Gerald,Weber, Stefan,Roemisch, Werner,Bacher, Adelbert,Fischer, Markus,Eisenreich, Wolfgang. "Photochemically induced dynamic nuclear polarization in a C450A mutant of the LOV2 domain of the Avena sativa blue-light receptor phototropin". . p. 17245 - 17252. Retrieved 2005.
• 3、 Choi, So Jung,Rhee, Hyun-Woo,Kim, Jihye,Chung, Doo Soo,Hong, Jong-In. "Fluorescent assay of cyclic nucleotide phosphodiesterase activity in a neutral aqueous solution". . p. 31 - 32. Retrieved 2013/08/24.