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7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione

Base Information Edit
  • Chemical Name:7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
  • CAS No.:83-88-5
  • Molecular Formula:C17H20N4O6
  • Molecular Weight:376.369
  • Hs Code.:29362300
  • NSC Number:758973
  • Wikidata:Q27167158
  • Metabolomics Workbench ID:123437
  • ChEMBL ID:CHEMBL1397833
  • Mol file:83-88-5.mol
7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione

Synonyms:Riboflavin (B2);Hyflavin;7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione;SR-05000001670;C17-H20-N4-O6;CAS-83-88-5;Riboflavin, USP grade;Spectrum2_000660;SCHEMBL7707;BSPBio_002264;SPECTRUM1505347;SPBio_000699;CHEMBL1397833;CHEBI:95299;HMS1922F06;HMS2093D07;Pharmakon1600-01505347;TNP00212;CCG-40022;NSC758973;NSC-758973;SDCCGMLS-0066869.P001;SMP1_000262;NCGC00016332-01;NCGC00016332-02;NCGC00016332-03;NCGC00017291-01;NCGC00178733-01;SBI-0206746.P001;FT-0645141;AB01563308_01;Riboflavin binding protein from chicken egg white;SR-05000001670-1;SR-05000001670-2;BRD-K70246307-001-02-5;BRD-K70246307-001-03-3;Q27167158;1195174-65-2

Suppliers and Price of 7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Riboflavin
  • 25g
  • $ 40.00
  • Usbiological
  • Vitamin B2
  • 96Tests
  • $ 1074.00
  • TRC
  • (-)-Riboflavin
  • 100g
  • $ 95.00
  • TCI Chemical
  • Riboflavin
  • 500g
  • $ 235.00
  • TCI Chemical
  • Riboflavin
  • 100g
  • $ 90.00
  • TCI Chemical
  • Riboflavin
  • 25g
  • $ 31.00
  • Sigma-Aldrich
  • Riboflavin (B2) analytical standard
  • 47861
  • $ 17.30
  • Sigma-Aldrich
  • Riboflavin (B2) analytical standard
  • 1000 mg
  • $ 17.90
  • Sigma-Aldrich
  • (?)-Riboflavin from Eremothecium ashbyii, ≥98%
  • 5g
  • $ 30.00
  • Sigma-Aldrich
  • (?)-Riboflavin from Eremothecium ashbyii, ≥98%
  • 25g
  • $ 29.70
Total 345 raw suppliers
Chemical Property of 7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione Edit
Chemical Property:
  • Appearance/Colour:Yellow to orange/yellow crystalline powder 
  • Melting Point:290 °C (dec.)(lit.) 
  • Refractive Index:-135 ° (C=0.5, JP Method) 
  • Boiling Point:504.93°C (rough estimate) 
  • PKA:1.7(at 25℃) 
  • Flash Point:9℃ 
  • PSA:161.56000 
  • Density:1.65 g/cm3 
  • LogP:-1.67520 
  • Storage Temp.:2-8°C 
  • Sensitive.:Light Sensitive 
  • Solubility.:Very slightly soluble in water, practically insoluble in ethanol (96 per cent). Solutions deteriorate on exposure to light, especially in the presence of alkali. It shows polymorphism (5.9). 
  • Water Solubility.:0.07 g/L (20 ºC) 
  • XLogP3:-1.5
  • Hydrogen Bond Donor Count:5
  • Hydrogen Bond Acceptor Count:7
  • Rotatable Bond Count:5
  • Exact Mass:376.13828437
  • Heavy Atom Count:27
  • Complexity:680
Purity/Quality:

Above 99% *data from raw suppliers

Riboflavin *data from reagent suppliers

Safty Information:
  • Pictogram(s): F,T 
  • Hazard Codes:F,T 
  • Statements: 11-23/24/25-39/23/24/25 
  • Safety Statements: 24/25-45-36/37-16 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)CC(C(C(CO)O)O)O
  • Isomeric SMILES:CC1=CC2=C(C=C1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@H]([C@H]([C@H](CO)O)O)O
  • Description A water-soluble B fraction was found in the 1920s to contain a yellow, fluorescent growth factor called riboflavin in England and vitamin G in the United States. In the early 1930s, several groups found the coenzyme forms of riboflavin 50-phosphate (flavin mononucleotide) and the further conjugate with adenylic acid (flavin adenine dinucleotide).
  • Physical properties Riboflavin is moderately soluble in water (10–13 mg/dl) and ethanol but insoluble in ether, chloroform, and acetone. It is soluble but unstable under alkaline conditions.The catalytic functions of riboflavin are carried out primarily at positions N-1, N-5, and C-4 of the isoalloxazine nucleus. In addition, the methyl group at C-8 participates in covalent bonding with enzyme proteins. The flavin coenzymes are highly versatile redox cofactors because they can participate in either one- or two electron redox reactionsRiboflavin antagonists include analogs of the isoalloxazine ring (e.g., diethylri boflavin, dichlororiboflavin) and the ribityl side chain (e.g., d-araboflavin, d-galactoflavin, 7-ethylriboflavin).
  • Uses Vitamin B2 (riboflavin) is produced by yeast from glucose, urea, and mineral salts in an aerobic fermentation. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor). Vitamin B2; Vitamin cofactor; LD50(rat) 560 mg/kg ip riboflavin (Vitamin B2) is used in skin care preparations as an emollient. It can be found in sun care products as a suntan enhancer. Medicinally, it is used for the treatment of skin lesions. Riboflavin is the water-soluble vitamin b2 required for healthy skin and the building and maintaining of body tissues. it is a yellow to orange-yellow crystalline powder. it acts as a coenzyme and carrier of hydrogen. it is stable to heat but may dissolve and be lost in cooking water. it is relatively stable to storage. sources include leafy vegetables, cheese, eggs, and milk.
  • Therapeutic Function Enzyme cofactor vitamin source
  • Clinical Use Severe riboflavin deficiency is known as ariboflavinosis, andtreatment or prevention of this condition is the only provenuse of riboflavin. Ariboflavinosis is most commonly associatedwith multiple vitamin deficiency as a result of alcoholismin developed countries. Because of the large numberof enzymes requiring riboflavin as a coenzyme, deficienciescan lead to a wide range of abnormalities. In adults seborrheicdermatitis, photophobia, peripheral neuropathy, anemia, andoropharyngeal changes including angular stomatitis, glossitis,and cheilosis, are often the first signs of riboflavin deficiency.In children, cessation of growth can also occur. As the deficiencyprogresses, more severe pathologies develop untildeath ensues. Riboflavin deficiency may also produce teratogeniceffects and alter iron handling leading to anemia.
Technology Process of 7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione

There total 48 articles about 7,8-dimethyl-10-((2R,3R,4S)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
In acetic acid; butan-1-ol; for 4h; Heating;
DOI:10.1007/BF00766881
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