1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone

Base Information

• Chemical Name: 1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone
• CAS No.: 905267-72-3
• Molecular Formula: C₃₃H₃₅N₇O₅
• Molecular Weight: 609.685
• Mol file: 905267-72-3.mol

Synonyms:1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone

Chemical Property of 1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone

There total 6 articles about 1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-[3,5-bis(6-aminopyridin-2-yl)carbamoyl]phenyl-2,6-dimethyl-4-pyridone (905267-71-2) + butyryl chloride (141-75-3) → 1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone (905267-72-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1002/anie.200504581

Reference yield:

1-(3,5-dicarbethoxy)phenyl-2,6-dimethyl-4-pyridone (905267-70-1) → 1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone (905267-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / t-BuLi / tetrahydrofuran / 20 h / 20 °C

2: 78 percent / Et₃N / tetrahydrofuran / 20 h / 20 °C

With tert.-butyl lithium; triethylamine; In tetrahydrofuran;

DOI:10.1002/anie.200504581

Reference yield:

1-(3,5-dicarboxy)phenyl-2,6-dimethyl-4-pyridone hydrochloride → 1-{3,5-bis[(6-butyrylamino)pyridin-2-yl]carbamoyl}phenyl-2,6-dimethyl-4-pyridone (905267-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / H₂SO₄ / toluene / 6 h / Heating

2: 55 percent / t-BuLi / tetrahydrofuran / 20 h / 20 °C

3: 78 percent / Et₃N / tetrahydrofuran / 20 h / 20 °C

With sulfuric acid; tert.-butyl lithium; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1002/anie.200504581

upstream raw materials:

1-[3,5-bis(6-aminopyridin-2-yl)carbamoyl]phenyl-2,6-dimethyl-4-pyridone

butyryl chloride

1-(3,5-dicarbethoxy)phenyl-2,6-dimethyl-4-pyridone

2.6-diaminopyridine