tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate

Base Information

Chemical Name:tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate
CAS No.:142535-28-2
Molecular Formula:C₂₉H₃₅NO₅
Molecular Weight:477.601
Hs Code.:

Synonyms:tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate

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Chemical Property of tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate

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Technology Process of tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate

There total 6 articles about tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 104436-91-1
t-butyl 4-bromomethyl-3-methoxybenzoate

: 142535-27-1
6-(2-cyclopentylethoxy)-3-formylindole

: 142535-28-2
tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 72h;
DOI:10.1021/jm00091a010

Reference yield:

: 24239-67-6
4-(benzyloxy)-1-methyl-2-nitrobenzene

: 142535-28-2
tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / dimethylformamide / 80 h / 130 °C

2: 39 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 0.5 h

3: 75 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

4: 1.) POCl₃, 2.) aq. NaOH / 1.) 0 deg C, 30 min, 2.) RT, 1 h, 3.) reflux, 5 min

5: 54 percent / K₂CO₃ / dimethylformamide / 72 h

With sodium hydroxide; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00091a010

Reference yield:

: 99474-13-2
(E)-5-(benzyloxy)-2-<2-(dimethylamino)vinyl>nitrobenzene

: 142535-28-2
tert-butyl 4-<<6-(2-cyclopentylethoxy)-3-formylindol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 0.5 h

2: 75 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran

3: 1.) POCl₃, 2.) aq. NaOH / 1.) 0 deg C, 30 min, 2.) RT, 1 h, 3.) reflux, 5 min

4: 54 percent / K₂CO₃ / dimethylformamide / 72 h

With sodium hydroxide; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00091a010