4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

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Chemical Name:4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide
CAS No.:1416468-24-0
Molecular Formula:C₄₈H₅₁N₇O₈
Molecular Weight:853.975
Hs Code.:

4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Synonyms:4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

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Technology Process of 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

There total 7 articles about 4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185837-25-5
4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid

: 1416470-03-5
7-{1-[(2R)-2-amino-3-phenylpropanoyl]piperidin-4-yl}-9-(3,4-dimethoxyphenyl)-7,8-diazaspiro[4.5]dec-8-en-6-one

: 1416468-24-0
4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 1416468-24-0
4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / 5 h / 160 °C / microwave irradiation

3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 1 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 0.75 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 2 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 5623-90-5
2-oxaspiro[4.4]nonane-1,3-dione

: 1416468-24-0
4-[5-(cyclopropylmethoxy)-1,3-benzodioxol-4-yl]-N-[(2R)-1-{4-[9-(3,4-dimethoxyphenyl)-6-oxo-7,8-diazaspiro[4.5]dec-8-en-7-yl]piperidin-1-yl}-1-oxo-3-phenylpropan-2-yl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / 5 h / 160 °C / microwave irradiation

3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 1 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 0.75 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 2 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;